Zinc promotes functional recovery after spinal cord injury by activating Nrf2/HO-1 defense pathway and inhibiting inflammation of NLRP3 in nerve cells.

Daoyong Li,He Tian,Xian Li,Liang Mao,Xiaoguang Zhao,Jiaquan Lin,Sen Lin,Chang Xu,Yuanye Liu,Yue Guo,Xifan Mei

Life Sciences（2020）

引用 55|浏览9

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摘要

Zinc has a protective effect on spinal cord injury by inhibiting oxidative damage and nlrp3 inflammation. Potential mechanisms may include activation of the Nrf 2/Ho-1 pathway to inhibit nlrp3 inflammation following spinal cord injury. Zinc has the potential to treat SCI.

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关键词

Zinc,Spinal cord injury,NLRP3 inflflammasome,Oxidative stress,NF-E2-related factor (Nrf2)

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