Single-cell analysis reveals new evolutionary complexity in uveal melanoma

Daniel A Rodriguez
Daniel A Rodriguez
Helen Snyder
Helen Snyder
Lynn G Feun
Lynn G Feun
Alan S Livingstone
Alan S Livingstone

Nature communications, pp. 496-10, 2020.

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Abstract:

Uveal melanoma (UM) is a highly metastatic cancer that, in contrast to cutaneous melanoma, is largely unresponsive to checkpoint immunotherapy. Here, we interrogate the tumor microenvironment at single-cell resolution using scRNA-seq of 59,915 tumor and non-neoplastic cells from 8 primary and 3 metastatic samples. Tumor cells reveal novel...More

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