Towards Accurate Visualization and Measurement of Localized Changes in Intraretinal Layer Thickness

Optical coherence tomography (OCT) enables high-resolution 3D imaging of intraretinal layers. The layers' thickness are commonly compared to normative data to understand a variety of retinal and systemic disorders. Yet, discovering and measuring localized thickness differences in the complex OCT data is challenging, particularly in an early stage of eye diseases. We combine interactive visualization and automated measurements to support the analysis of abnormal layer thickness. First, the spatial distribution of thickness differences is visualized via precise deviation maps. Second, statistical tests are applied to quantify every point of the visualized data. Third, measurements of significant differences for anatomically distinct areas and selected regions of interest are retrieved. We demonstrate the effectiveness of our solution in detecting abnormal layer thickness in the context of a cross-sectional ophthalmic study.