Crosstalk between endothelial cell-specific calpain inhibition and the endothelial-mesenchymal transition via the HSP90/Akt signaling pathway.

Xiaodi Sun,Yujiao Sun, Pengcheng Jiang,Guoxian Qi,Xitao Chen

Biomedicine & Pharmacotherapy（2020）

引用 14|浏览11

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摘要

•Canonical TGF-β1 triggers Endothelial-Mesenchymal Transition by activating calpain.•Endothelial cell calpain deletion ameliorates cardiac fibrosis and hypertrophy.•Overexpression of calpastatin reverses Endothelial-Mesenchymal Transition in vitro.•Calpain inhibition contributes to alleviating EndMT via blocking HSP90/Akt signaling.

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关键词

EC-calpain,Cardiac fibrosis,HSP90,p-Akt,VE-cadherin,α-SMA,Endothelial-mesenchymal transition

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