Tissue-Engineered Vascular Grafts with Advanced Mechanical Strength from Human iPSCs

Jiesi Luo
Jiesi Luo
Liping Zhao
Liping Zhao
Matthew W Ellis
Matthew W Ellis
J Alexander Clark
J Alexander Clark
Shun Ono
Shun Ono
Yifan Yuan
Yifan Yuan
Shang-Min Zhang
Shang-Min Zhang

Cell stem cell, 2020.

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Keywords:
human induced pluripotent stem cellstissue engineered vascular graftsvascular smooth muscle cells

Abstract:

Vascular smooth muscle cells (VSMCs) can be derived in large numbers from human induced pluripotent stem cells (hiPSCs) for producing tissue-engineered vascular grafts (TEVGs). However, hiPSC-derived TEVGs are hampered by low mechanical strength and significant radial dilation after implantation. Here, we report generation of hiPSC-derive...More

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