The role of exosomes in colorectal cancer disease progression and response to therapy.

•Shuttling of exosome contents through body fluids contributes to CRC development and progression.•CRC exosomes reprogram neighboring cells to colonize distant target organs, thus favouring metastasis.•Exosomes from tumor cells or non-immune stromal cells contribute to CRC progression by hijacking APCs and effector T cells.•Exosomes are promising biomarkers for diagnosis, prognosis and therapy resistance in CRC.