Combined treatment with vitamin D3 and antibody agents suppresses secondary heart transplant rejection in the early postoperative period.

Baiyi Xie,Yunhan Ma,Yanfeng Xi,Anjie Di, Xu Chen,Yingyu Chen,Liyi Zhang,Shuangyue Xu,Chenxi Wang,Guoliang Yan,Zhongquan Qi

Transplant Immunology（2020）

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摘要

•Treatment with antibodies plus activated vitamin D extended allograft survival time in allo-primed recipient.•It decreased inflammatory cell infiltration and inhibited IL-2 and IFN-γ expression.•Protection was due to a decrease in the number of CD44(high) CD62L+ memory T cells and increase in the number of Treg.

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关键词

Vitamin D3,Rejection,Heart transplantation,Memory T cells

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