Similarities and differences in the effects of sensitisation and challenge with Dermatophagoides farinae and Dermatophagoides pteronyssinus extracts in a murine asthma surrogate
Cellular Immunology(2020)
摘要
•We present a comparison of the effects of Dermatophagoides farinae and Dermatophagoides pteronyssinus in a murine asthma surrogate.•Mice challenged with Der f showed significantly poorer lung tissue elasticity and higher MMP9 and MMP12 expression.•Mice challenged with Der p showed significantly higher corticosteroid-resistant related cytokines and neutrophil infiltration.
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关键词
AHR,Der f,Der p,OVA,Mch,BALF,PBS,H&E,PAS,IHC,MMP,MCPT-1
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