Reverse poly(ε-caprolactone)-g-dextran graft copolymers. Nano-carriers for intracellular uptake of anticancer drugs.

•Synthesis of a reverse oligosaccharide-based poly(ε-caprolactone)-g-dextran copolymer.•Preparation of cytocompatible and biodegradable Doxorubicin-loaded polymeric micelles.•pH-sensitive release of Doxorubicin from Doxorubicin-loaded micelles.•Selective internalization of Poly(ε-caprolactone)-g-dextran micelles in cancer cells.•Selective death of colorectal cancer cells by Doxorubicin-loaded micelles.