Mir-455-3p Functions As A Tumor Suppressor In Colorectal Cancer And Inhibits Cell Proliferation By Targeting Tpt1
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY(2018)
摘要
increasing studies have revealed the importance of microRNAs (miRNAs) in tumorigenesis and tumor progression. miR-455-3p is a newly identified tumor suppressive RNA in various human cancers. However, the expression pattern and clinical significance of miR-455-3p in colorectal cancer (CRC) remains unclear. We found that expression of miR-455-3p was significantly reduced in CRC tissues and cell lines. In addition, we show that low miR-455-3p expression is associated with larger tumor size, advanced tumor stage, and poorer overall survival of CRC patients. Furthermore, in vitro experiments revealed that overexpression of miR-455-3p represses cell proliferation. Importantly, we show that the tumor protein translationally controlled 1 (TPT1) is a direct target of miR-455-3p. Moreover, expression of TPT1 was inversely correlated with the expression of miR-455-3p. Loss-of-function of TPT1 had a similar effect on CRC cell proliferation in vitro as gain-of-function of miR-455-3p. Taken together, these data suggest that miR-455-3p functions as tumor suppressive RNA by targeting TPT1 in CRC, and it might be a potential therapeutic target for CRC patients.
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关键词
miR-455-3p, TPT1, colorectal cancer, proliferation, cell cycle
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