Effects of donor–recipient combinational CYP3A5 genotypes on tacrolimus dosing in Chinese DDLT adult recipients

Jianyu Liu,Dexi Chen,Bo Yao,Ge Guan,Chao Liu,Xinmin Jin,Xin Wang,Peng Liu,Yandong Sun,Yunjin Zang

International Immunopharmacology（2020）

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摘要

•Genetic factors contributed the most to Tac C/D variability.•The effect of the recipient’s genetics was correlated only in the first three months.•The role of the donor CYP3A5 genotype was observed throughout the timeline.•The donor’s liver CYP3A5 genotype contributed increasingly after transplantation.

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关键词

Liver transplant,Tacrolimus,Recipient,Donor,CYP3A5 genotype

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