JQ1 inhibits tumour growth in combination with cisplatin and suppresses JAK/STAT signalling pathway in ovarian cancer.

Tina Bagratuni,Nefeli Mavrianou,Nikolaos G Gavalas,Kimon Tzannis, Calliope Arapinis,Michael Liontos,Maria I Christodoulou,Nikolaos Thomakos,Dimitrios Haidopoulos,Alexandros Rodolakis,Efstathios Kastritis,Andreas Scorilas,Meletios A Dimopoulos,Aristotle Bamias

European Journal of Cancer（2020）

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摘要

•JQ1 suppresses cell survival and induces apoptosis in ovarian cancer by targeting BRD4 and c-Μyc.•JQ1 demonstrates antisurvival effects in ovarian cells, which exhibit resistance to cisplatin.•JQ1 interacts with JAK-STAT pathway by differentiating genes involved in survival and apoptosis.

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关键词

JQ1,BRD4,c-Myc,Ovarian,JAK/STAT

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