Mice with pre-existing tumors are vulnerable to postoperative cognitive dysfunction.

Tong Wu,Xiaoqiang Wang,Ruirui Zhang,Yingfu Jiao,Weifeng Yu,Diansan Su,Yanhua Zhao,Jie Tian

Brain Research（2020）

引用 8|浏览53

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摘要

•Tumor-bearing adult mice are vulnerable to POCD.•Surgery induces prolonged hippocampal inflammation in tumor-bearing adult mice.•Prolonged central inflammation is derived from heightened peripheral innate immunity.

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关键词

CBA,Iba-1,IL-1β,IL-2,IL-4,IL-17,IFN-,IL-6,MDSCs,NOR,POCD,PSD-95,TNF-α,MWM

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