Dopamine transporter gene expression within the nucleus accumbens plays important role in the acquisition and reinstatement of ethanol-seeking behavior in mice.

Behavioural Brain Research（2020）

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摘要

•Accumbal DAT knockdown decreased EtOH-CPP acquisition.•Following extinction, DAT knockdown decreased EtOH-primed CPP reinstatement.•Accumbal DAT overexpression exacerbated EtOH-CPP acquisition.•Following extinction, DAT overexpression increased EtOH-primed CPP reinstatement.•In the NAcc, DAT mRNA expression correlated with measures of EtOH-CPP.

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关键词

CPP,DA,DAT,EtOH,LV,Nacc,shRNA

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