SUL-109 protects hematopoietic stem cells from apoptosis induced by short-term hypothermic preservation and maintains their engraftment potential.

•SUL-109, a newly developed 6-chromanol derivate, is an easy-to-use, nontoxic cell culture additive that provides protection during hypothermic storage of hematopoietic stem cells (HSCs).•SUL-109 improves cell survival of immature CD34+/CD38- cells during hypothermic storage and preserves the multilineage capacity of human CD34+ UCB cells.•SUL-109 effectively lowers reactive oxygen species during hypothermic storage and preserves the engraftment potential of HSCs after hypothermia.