BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins

Meng Jiang
Meng Jiang
Yue Kang
Yue Kang
Jiao Wang
Jiao Wang
Helen Tanton
Helen Tanton
Keith Alder
Keith Alder
Peter Dennis
Peter Dennis
Zhongqiu Wang
Zhongqiu Wang
Ruiyang Liu
Ruiyang Liu
Mengyun Zhang
Mengyun Zhang

Nature communications, pp. 192020.

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Abstract:

Colorectal cancer (CRC) is the third most commonly diagnosed cancer, which despite recent advances in treatment, remains incurable due to molecular heterogeneity of tumor cells. The B-cell lymphoma 9 (BCL9) oncogene functions as a transcriptional co-activator of the Wnt/β-catenin pathway, which plays critical roles in CRC pathogenesis. He...More

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