The NMDAR modulator NYX-2925 alleviates neuropathic pain via a Src-dependent mechanism in the mPFC.

Gladys Morrison, Marina N Asiedu,Jessica M Priebe, Jacqueline Dunning,Nayereh Ghoreishi-Haack,Roger A Kroes,M Scott Bowers,Amanda L Barth,Cassia N Cearley,Joseph R Moskal

Neurobiology of Pain（2020）

引用 1|浏览12

暂无评分

摘要

•Direct injection of the NMDAR modulator NYX-2925 in the mPFC, reverses allodynia.•Src activity is downregulated in the mPFC of a CCI neuropathic pain model.•NYX-2925 restores pain induced decrease of phosphorylated NMDAR’s.•NYX-2925 restores pain induced decrease of Src-mediated intracellular signaling.

查看译文

关键词

Neuropathic pain,Medial prefrontal cortex,NMDAR's,Src kinase,Chronic Constriction injury (CCI)

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要