Modulation of Human Neutrophil Peptides on P. aeruginosa Killing, Epithelial Cell Inflammation and Mesenchymal Stromal Cell Secretome Profiles

Qingqing Dai
Qingqing Dai
Yasumasa Morita
Yasumasa Morita
Jianfeng Wu
Jianfeng Wu
Julie Khang
Julie Khang
Kaijiang Yu
Kaijiang Yu

Journal of inflammation research, pp. 335-343, 2019.

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Keywords:
cytokinesdefensinslung injurysepsis

Abstract:

Stimulation of MSCs with HNP resulted in changes of secretome profiles at 5-fold lower concentration than that required for bacterial killing and lung epithelial inflammation. This undisclosed risk factor of HNP in lung environment should be taken into consideration when MSCs are applied as cell therapy in inflammatory lung diseases.

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