Modulation of Human Neutrophil Peptides on P. aeruginosa Killing, Epithelial Cell Inflammation and Mesenchymal Stromal Cell Secretome Profiles

    Qingqing Dai
    Qingqing Dai
    Yasumasa Morita
    Yasumasa Morita
    Jianfeng Wu
    Jianfeng Wu
    Julie Khang
    Julie Khang
    Kaijiang Yu
    Kaijiang Yu

    Journal of inflammation research, pp. 335-343, 2019.

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    Keywords:
    cytokinesdefensinslung injurysepsis

    Abstract:

    Stimulation of MSCs with HNP resulted in changes of secretome profiles at 5-fold lower concentration than that required for bacterial killing and lung epithelial inflammation. This undisclosed risk factor of HNP in lung environment should be taken into consideration when MSCs are applied as cell therapy in inflammatory lung diseases.

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