In vitro response and gene expression of human retinal Müller cells treated with different anti-VEGF drugs.

Javier Cáceres-Del-Carpio,M Tarek Moustafa,Jaime Toledo-Corral,Mohamed A Hamid,Shari R Atilano,Kevin Schneider,Paula S Fukuhara,Rodrigo Donato Costa, J Lucas Norman,Deepika Malik,Marilyn Chwa,David S Boyer,G Astrid Limb,M Cristina Kenney,Baruch D Kuppermann

Experimental eye research（2020）

引用 6|浏览27

暂无评分

摘要

•Human retinal Müller cells (MIO-M1) were treated with 4 different anti-VEGF drugs.•Cultures had decreased metabolism, viability and mitochondrial membrane potential.•Treatment led to higher levels of ROS and apoptosis.•Altered expression of angiogenesis, pro-apoptosis and inflammatory genes were found.•Anti-VEGF drugs may contribute to cytotoxicity associated with chronic injections.

查看译文

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要