Segmentation of cellular patterns in confocal images of melanocytic lesions in vivo via a multiscale encoder-decoder network (MED-Net)

•In-vivo imaging based non-invasive diagnosis is advancing into clinical practice.•MED-Net mimicks clinicians’ examination of in vivo RCM images by multiscale analysis.•Trained and tested on 117 RCM mosaics collected at 6 clinics in 2 countries.•An efficient training strategy via multi-scale deep supervision.•Multi-scale analysis capability of MED-Net increase in vivo segmentation performance.