Donor KIR2DS1-mediated Decreased Relapse and Improved Survival, Depending on Remission Status at HLA-Haploidentical Transplantation with Post-transplantation Cyclophosphamide.

Kentaro Ido,Hideo Koh,Asao Hirose,Hiroshi Okamura,Shiro Koh,Satoru Nanno,Mitsutaka Nishimoto,Mika Nakamae,Yasuhiro Nakashima,Takahiko Nakane,Masayuki Hino,Hirohisa Nakamae

Biology of Blood and Marrow Transplantation（2020）

引用 7|浏览31

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摘要

•Donor KIR2DS1 was associated with reduced risk of relapse after HLA-haploidentical allogeneic hematopoietic cell transplantation (allo-HCT) using post-transplantation cyclophosphamide (PT/Cy-haplo).•Donor KIR2DS1 was associated with improved overall survival with PT/Cy-haplo.•GVL effect via NK cell alloreactivity was exerted in CR, but not in non-CR.•Donor KIR genotyping and disease status should be assessed for donor selection.•Elucidating mechanisms involved could lead to novel strategies for relapse therapy.

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关键词

Killer-cell immunoglobulin-like receptor genotyping,KIR2DS1,HLA-haploidentical allogeneic hematopoietic cell transplantation,Post-transplantation cyclophosphamide,Complete remission,Relapse,Prognosis,Survival

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