Association of neuronal repair biomarkers with delirium among survivors of critical illness.

Christina J Hayhurst,Mayur B Patel,J Brennan McNeil,Timothy D Girard,Nathan E Brummel,Jennifer L Thompson,Rameela Chandrasekhar,Lorraine B Ware,Pratik P Pandharipande,E Wesley Ely,Christopher G Hughes

Journal of Critical Care（2020）

引用 7|浏览50

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摘要

•A hypothesis on the pathogenesis of delirium in critically ill is neuroinflammation.•One neuronal repair biomarker, UCHL1, is associated with prevalence of ICU delirium.•Another biomarker, BDNF, is not associated with delirium.•Ubiquitin proteasome pathway might maintain brain function during critical illness.

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关键词

Brain-derived neurotrophic factor,Critical illness,Cognitive dysfunction

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