Comparative Biochemical Outcomes, Effectiveness And Tolerance Of Densiron 68 And Oxane Hd For The Management Of Complicated Retinal Detachment

Objectives: To compare biochemical outcomes, effectiveness, and tolerance of two high-density silicone oils (HDSOs), silicone oil-RMN3 (Oxane (R) HD) and silicone oil-Densiron-68 (Densiron (R) 68), for the management of complicated retinal detachment (RD) associated with inferior proliferative vitreoretinopathy (PVR).Materials and Methods: This was a retrospective, single-centre, comparative case series of 23 patients treated between September 2014 and June 2016. The main inclusion criteria were RD with inferior PVR receiving Oxane (R) HD or Densiron (R) 68 following pars plana vitrectomy. The main outcome measures were anatomical success, rate of RD recurrence, and best-corrected visual acuity (BCVA) at 6 months. Secondary outcomes were short-term complications.Results: Twenty-three eyes were included: 16 eyes with Densiron (R) 68 tamponade and 7 eyes with Oxane (R) HD tamponade. Anatomical success under HDSO was significantly higher in the Densiron (R) 68 group (100%) than in the Oxane (R) HD group (42.8%) (p=0.0455). Recurrent RD was observed in 42.8% of eyes under Oxane (R) HD, but in none of the patients under Densiron (R) 68 (p=0.001). Six months after surgery, mean BVCA values (+/- standard deviation) with Densiron (R) 68 and Oxane (R) HD were 0.83 +/- 0.62 logMAR and 1.81 +/- 0.65 logMAR, respectively. BVCA was significantly better in the Densiron (R) 68 group (p=0.006). No significant differences were observed with regard to intraocular pressure, emulsification, or intraocular inflammation.Conclusion: Densiron (R) 68 appears to be more effective than Oxane (R) HD for the management of RD associated with PVR. A randomized, controlled, interventional study is needed to demonstrate this difference.