Design, synthesis and biological evaluation of substituted 2-(thiophen-2-yl)-1,3,5-triazine derivatives as potential dual PI3Kα/mTOR inhibitors.

Binliang Zhang,Qian Zhang,Zhen Xiao,Xin Sun,Zunhua Yang,Qi Gu, Ziqin Liu,Ting Xie,Qingqing Jin,Pengwu Zheng,Shan Xu,Wufu Zhu

Bioorganic Chemistry（2020）

引用 15|浏览7

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摘要

The preparation and biological evaluation of a series of substituted 2-(thiophen-2-yl)-1,3,5-triazine derivatives were disclosed, which demonstrated potent inhibition of the PI3K/AKT/mTOR pathway, culminating in the discovery of 13g.

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关键词

2-(Thiophen-2-yl)-1,3,5-triazine,PI3Kα/mTOR inhibitors,Anti-tumor activity,Scaffold hopping

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