Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)validation.
Julie Farand,Jeffrey E. Kropf,Peter Blomgren,Jianjun Xu,Aaron C. Schmitt,Zachary E. Newby,Ting Wang,Eisuke Murakami,Ona Barauskas,Jawahar Sudhamsu,Joy Y. Feng,Anita Niedziela-Majka,Brian E. Schultz,Karen Schwartz,Serge Viatchenko-Karpinski,Dmytro Kornyeyev,Adam Kashishian,Peidong Fan,Xiaowu Chen,Eric B. Lansdon,Michael O. Ports,Kevin S. Currie,William J. Watkins,Gregory T. Notte ACS Medicinal Chemistry Letters（2019）
关键词
MutT homologue 1(MTH1) inhibition,8-oxo-dGTP,tetrahydronaphthyridine,triazolopyridine,DNA damage
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