Integrative modelling of biomolecular complexes

In recent years, the use of integrative, information-driven computational approaches for modeling the structure of biomolecules has been increasing in popularity. These are now recognized as a crucial complement to experimental structural biology techniques such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy and cryo-electron microscopy (cryo-EM). This trend can be credited to a few reasons such as the increased prominence of structures solved by cryo-EM, the improvements in proteomics approaches such as cross-linking mass spectrometry (XL-MS), the drive to study systems of higher complexity in their native state, and the maturation of many computational techniques combined with the widespread availability of information-driven integrative modeling platforms.