T-DM1 EFFICACY AND ACTIVITY IN HER2-POSITIVE METASTATIC BREAST CANCER PATIENTS PROGRESSING AFTER FRONTLINE TAXANE PLUS PERTUZUMAB AND TRASTUZUMAB: AN ITALIAN MULTICENTER OBSERVATIONAL STUDY OF THE GRUPPO ITALIANO MAMMELLA (GIM) STUDY GROUP

Background: Invasive lobular cancers (ILC) constitute 5%, 15% of all invasive breast tumors, less common than invasive ductal carcinoma (IDC), and appear to have a distinct biology. The aim of our study is to determine the ILC biological profile collected in the department of oncology medical Tizi Ouzou hospital Algeria. Materials and methods: We recorded the cases of 80 patients with ILC between January 2012 and January 2014. The aim of this study is to evaluate the clinical and pathological response, molecular profiling using RE, RP, KI67, HER2, and the follow up between (2012–2017).Result: The average age of patients with ILC is 51 years, 40% women have postmenopausal status, all patients underwent mammography, diagnosed by a core needle biopsy, the commonest stage at presentation was stage III (42%). 10 patients (12, 5%) underwent a breast conserving surgery, and 87% a mastectomy. The …