Local depigmentation as a sign of local recurrence of a histologic complete regressed malignant melanoma

Malignant melanoma is an immunogenic tumor that derives from transformed melanocytes.1 These tumors can be infiltrated by T lymphocytes, and this could cause destruction of normal melanocytes, which is clinically evident as leukoderma.2 Several leukodermas are described in melanomas: primary melanoma regression, halo nevi, and melanoma-associated depigmentation, which either occurs spontaneously or after immunologic-based treatment.3 Complete primary melanoma regression is a rare finding with no consensus about the prognostic significance.