Efficacy of Korean red ginseng (Panax ginseng) for middle-aged and moderate level of chronic fatigue patients: A randomized, double-blind, placebo-controlled trial

•Chronic fatigue (CF) is unexplained fatigue lasting more than 6 months and its symptoms interfere with the quality of life.•While Korean red ginseng (KRG) is known to have higher anti-fatigue substance, its efficacy and safety for CF is unknown.•Our study provided KRG's therapeutic potential for middle-aged individuals with moderate fatigue with objective evidence.