The role of neutrophils in neuro-immune modulation

Alexandre Kanashiro,Carlos Hiroji Hiroki,Denise Morais da Fonseca,Alexander Birbrair,Raphael Gomes Ferreira,Gabriel Shimizu Bassi, Mirian D. Fonseca,Ricardo Kusuda,Guilherme Cesar Martelossi Cebinelli, Katiussia Pinho da Silva,Carlos Wagner Wanderley,Gustavo Batista Menezes,José Carlos Alves-Fiho,André Gustavo Oliveira,Thiago M. Cunha,André Sampaio Pupo,Luis Ulloa,Fernando Queiroz Cunha

Pharmacological Research（2020）

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摘要

•Neutrophils are an immunological and diffuse source of neurotransmitters.•Neutrophils regulate sensory neuron functions and vice-versa.•Neutrophils play a crucial role in inflammatory disorders in the central nervous system.

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ACh,ARs,βARs,BBB,C5a,CFA,CGD,CGRP,CNS,DAMPs,DHPG,DRG,ELISA,fMLP,GRP,H+,H2O2,HMGB-1,HOCl,HPLC,ICAM-1,IFN,IL,iNOS,InsP7,IκB,LTB4,mAChRs,MET,MPO,MS,nAChRs,NETs,NF-κB,NK,NO,PAMPs,PGE2,PMA,RNS,ROS,SP,TH,TNF-α,VIP,VLA-4,VMAT,α7nAChR

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