Synergistic anticancer effects of electrospun nanofiber-mediated codelivery of Curcumin and Chrysin: Possible application in prevention of breast cancer local recurrence
Journal of Drug Delivery Science and Technology(2020)
摘要
To decrease the locoregional recurrence of breast cancer, the in vitro anticancer efficacy of electrospun nanofibers (NFs) co-loaded with Curcumin (Cur) and Chrysin (Chr), as natural anticancer compounds, against T47D breast cancer cells was evaluated. According to FE-SEM results, the randomly oriented bead-free CurChr co-loaded PLGA/PEG fibers presented more interconnection among the fibers with increased average diameter to around 800 nm. Also, co-loading Cur and Chr into the NFs improved mechanical properties than single drug-loaded NFs. The in vitro release profile indicated the almost identical and prolonged release profile of drugs from CurChr-NFs that were lower than that from Cur-NFs and Chr-NFs. Based on MTT, CurChr-loaded PLGA/PEG NFs displayed effectively synergistic antiproliferative activities than the single drug-loaded NFs. Among loading different non-constant ratios of Cur and Chr in polymeric NFs, 10:5% (wt:wt%) CurChr-NFs exhibited the best synergistic cytotoxicity against the cells and could further altered the mRNA levels of bax, bcl-2, p53, Cyclin D1, caspase-3, caspase-7, and hTERT genes. In conclusion, the dual drug-loaded NFs showed an excellent capacity to inhibit T47D breast cancer cells in vitro than the single drug-encapsulated NFs. Therefore, the fabricated dual drug-encapsulated NFs may achieve a safe and suitable application for breast cancer relapse rate after surgery.
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关键词
Nanofiber,Curcumin,Chrysin,Breast cancer,Combination chemotherapy
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