Diagnostic And Therapeutic Decision Making In Pediatric Patients With Low Von Willebrand Factor

Introduction: Low VWF is an intermediate reduction in VWF between the normal range and type 1 VWD. Assessment of the clinical relevance of low VWF is difficult due to the wide interpatient variability in bleeding phenotype, especially in children who often have no prior hemostatic challenges. A standard approach to diagnosing and treating low VWF in pediatric patients is lacking. This study aims to characterize the archetypes of pediatric patients with low VWF and create a diagnostic and therapeutic workflow for subsequent prospective validation.