Complement C3a Not C4a Activates Osteoclasts By Regulating The Pi3k/Pdk1/Sgk3 Pathway In Patients With Multiple Myeloma

Objective: Myeloma bone disease (MBD) is the most common complication of multiple myeloma (MM). We found that the serum levels of C3/C4 in MM patients were significantly positive correlated with the severity of bone disease in our previously study. Thus, we conduct detailed studies to explore the effect and potential mechanism of C3a/C4a on osteoclasts in patients with MM.