Identification Of St3gal6-As1 Interactive Protein In Multiple Myeloma

Introduction: Multiple myeloma (MM) is a malignancy of antibody-secreting plasma cells (PCs) characterized by the clonal expansion and accumulation of monotypic PCs in the bone marrow (BM). Despite the remarkable improvements have been done in knowledge on the pathobiology of MM, therapy and medical care, MM still remains an incurable disease. Therefore elucidation of regulatory circuits altered such as long non-coding RNAs (lncRNAs) will allow us to obtain a better understanding into the biology and targeted therapy of MM. Overwhelming evidence suggests that lncRNAs have huge impact on adjusting gene expression through the processes of transcription and post-transcription regulation, genomic imprinting, and chromatin modification. In our previous study, we validated one lncRNA named ST3 beta-galactoside alpha-2,3-sialyltransferase 6 antisense RNA 1 (ST3GAL6-AS1) which was upregulated markedly in MM patients. Further research revealed that ST3GAL6-AS1 promote the adhesion, migration and invasion ability of MM cells. To determine the precise mechanism underlying ST3GAL6-AS1 biological function, we expound its interactive protein in this study.