Blinatumomab-induced T cell activation at single cell transcriptome resolution.

Yi Huo,Zhen Sheng,Daniel R Lu,Daniel C Ellwanger,Chi-Ming Li,Oliver Homann,Songli Wang,Hong Yin,Ruibao Ren

BLOOD（2021）

引用 11|浏览11

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摘要

These results reveal a target cell-dependent mechanism of T-cell activation by blinatumomab and suggest that TNFSF4 may be responsible for the resistant mechanism and a potential target for combination therapy with blinatumomab, to treat B-ALL or other B-cell malignancies.

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关键词

Acute B cell lymphoblastic leukemia,Bi-specific T-cell engager antibody,Blinatumomab,Single-cell RNA-Seq,T cell activation,TNFRSF4

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