Clinical Relevance Of Myd88 L265p Mutation And Interleukin-10 Level In Cerebrospinal Fluid Of Patients With Both Newly Diagnosed And Relapsed Primary Diffuse Large B-Cell Lymphoma Of The Central Nervous System

Introduction: Early diagnosis remains a major concern in pts with primary diffuse large B-cell lymphoma (DLBCL) of the CNS (PCNSL). Diagnostic delay leads to severe neurological impairment due to prolonged exposure of CNS tissues to tumor infiltration, and protracted steroid therapy, which causes immunodepression and infective complications, the main reasons for treatment interruptions. A few molecular markers have been proposed as diagnostic tools, but reliable parameters that can be easily incorporated in routine practice are still needed. Near 70% of PCNSLs display MYD88 L265P mutation and release high levels of interleukin-10 (IL10). These two parameters are widely used for routine diagnosis of different disorders, but are hardly detectable in peripheral blood of PCNSL pts; accordingly, cerebrospinal fluid (CSF) may be an attractive alternative for their evaluation. Thus, we investigated the …