Aurora Kinase A/Mdm2-Mediated Setd2 Loss Of Function In Chronic Myeloid Leukemia Patients In Blast Crisis Can Be Therapeutically Targeted Inducing Apoptotic Cell Death In A Caspase-Dependent Way

One of the hallmarks of chronic myeloid leukemia (CML) is genomic instability, that fosters the acquisition of tyrosine kinase inhibitor (TKI)-resistant BCR-ABL1 mutations and/or of additional chromosomal aberrations leading to progression to blast crisis (BC).