Combined treatment with 9-cis β-carotene and 22R-hydroxycholesterol augments cholesterol efflux in macrophages

Lidor Mahler,Ayelet Harari,Dror Harats,Ami Ben-Amotz,Michael Peled,Alicia Leikin-Frenkel,Michal Kandel Kfir,Yehuda Kamari,Aviv Shaish

Algal Research（2019）

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摘要

•9-cis-β-carotene and 22-hydroxycholesterol combined, enhanced cholesterol efflux.•Liarozole increased 9-cis-β-carotene favorably effect on macrophage cholesterol efflux.•Macrophages, isolated from Dunaliella-fed mice, performed high cholesterol efflux.

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关键词

9-cis β-carotene (9CBC),Cholesterol efflux,22R-hydroxycholesterol (22-HC),Liarozole,Liver X receptor (LXR),Retinoic X receptor (RXR)

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