Promising method in formulating ocular bio-adhesive inserts of ciprofloxacin hydrochloride combination with xanthan gum and carbopol

Ciprofloxacin hydrochloride (CFX-HCl) is an antibiotic used to treat bacterial infections in different parts of the body. This study outlines the development and characterization of a controlled-release CFX-HCl drug delivery system. The study utilized propylene glycol (PG), carbopol 934P (C-934), and xanthan gum (XG) micro-encapsulated via the spray-drying method. According to British Pharmacopoeia, the drug delivery systems were sterilized with the assistance of gamma radiation. Investigation of the spray-dried powder was carried out by scanning electron microscopy (SEM). Stability studies were also performed. The systems displayed sustained and controlled release of CFX-HCl in in vitro studies over a prolonged period. The shelf-life of the product containing PG was determined to be greater than two years. Such systems, which are physically and chemically stable, may yield huge therapeutic benefits in the management of conjunctivitis and corneal ulceration.