Adamdec1 And Fgf2/Fgfr1 Signaling Constitute A Positive Feedback Loop To Maintain Gbm Cancer Stem Cells

Identification of targetable mechanisms that maintain glioblastoma cancer stem cells (CSCs) remain a priority. Our study reveals a new mechanism by which a disintegrin and metalloproteinase domain-like protein decysin 1 promotes CSC maintenance through the activation of a fibroblast growth factor autocrine signaling loop, which can be blocked pharmacologically.