Linking the low-density lipoprotein receptor-binding segment enables the therapeutic 5-YHEDA peptide to cross the blood-brain barrier and scavenge excess iron and radicals in the brain of senescent mice

Zhenyou Zou,Shengxi Shao,Ruyi Zou, Jini Qi,Liguan Chen,Hui Zhang, Qiqiong Shen,Yue Yang,Liman Ma, Ruzeng Guo,Hongwen Li,Haibo Tian, Pengxin Li, Mingfang Yu,Lu Wang, Wenjuan Kong, Caiyu Li, Zhenhai Yu,Yuping Huang,Li Chen, Qi Shao,Xinyan Gao, Xiaolin Chen, Zhengbo Zhang,Jianguo Yan,Xiaoyun Shao,Ru Pan,Lu Xu, Jing Fang, Lei Zhao, Yaohui Huang, Anqi Li, Yuchong Zhang, Wenkao Huang, Kechun Tian, Minxin Hu, Linchao Xie, Lingbin Wu, Yu Wu, Zhen Luo, Wenxin Xiao, Shanshan Ma, Jianan Wang,Kaixin Huang, Siyuan He, Fan Yang, Shuni Zhou, Mo Jia,Hongsheng Lu,Xinjuan Wang,Jie Tan

Alzheimer's & Dementia: Translational Research & Clinical Interventions（2019）

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摘要

bs-5-YHEDA may be a mild and safe iron remover that can cross the BBB and enter the brain to relieve excessive iron- and radical-induced cognitive disorders.

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关键词

Alzheimer's disease,Senescent mouse,bs-5-YHEDA,Blood-brain barrier,LDLR,ApoB-100,Iron,Radicals

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