Statin Therapy Improves Fractional Catabolic Rate of LDL without Affecting Impaired VLDL and VLDL Remnant Catabolism in Homozygous FH Patient Due to PCSK9 Gene Mutation: Evidence from Kinetic Study with Stable Isotope

Masa-aki Kawashiri,Katsunori Ikewaki,Hayato Tada,Tohru Noguchi,Atsushi Nohara,Akihiro Inazu,Junji Kobayashi,Hiroshi Mabuchi,Masakazu Yamagishi

Circulation（2012）

引用 23|浏览6

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摘要

Background: Statin decreases plasma low-density lipoprotein (LDL) cholesterol through activation of sterol regulatory element binding protein 2 (SREBP2) and ensuing induction of LDL receptor. SREBP...

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关键词

Hyperlipoproteinemia,Metabolism,Lipoproteins,Statins

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