Pyruvate Protects Against Intestinal Injury by Inhibiting the JAK/STAT Signaling Pathway in Rats With Hemorrhagic Shock.

Jing-Jing Zhang,Jiang-Tao Deng,Hui-Qin Shen,Lin-Lin Jiang,Qian-Wen He,Jia Zhan,Zong-Ze Zhang,Yan-Lin Wang

Journal of Surgical Research（2020）

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摘要

The protection mechanism of PR with PY-PDS combined with VR was related to the inhibition of the JAK/STAT signaling pathway during HS and resuscitation. The process might include suppression of oxidative stress, reduction of neutrophil infiltration, regulation of microcirculation, and inhibition of apoptosis.

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关键词

Peritoneal resuscitation,Hemorrhagic shock,Ischemia-reperfusion injury,Oxidative stress,Apoptosis

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