Use of human neuroblastoma SH-SY5Y cells to evaluate glyphosate-induced effects on oxidative stress, neuronal development and cell death signaling pathways.

María-Aránzazu Martínez,José-Luis Rodríguez,Bernardo Lopez-Torres,Marta Martínez,María-Rosa Martínez-Larrañaga,Jorge-Enrique Maximiliano,Arturo Anadón,Irma Ares

Environment International（2020）

引用 110|浏览7

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摘要

•Cytotoxicity and neurotoxicity of glyphosate and AMPA in SH-SY5Y cells.•Glyphosate and AMPA decrease MTT cell viability and increased LDH leakage.•Glyphosate and AMPA increase MDA, NO and ROS production, and caspase-3/7 activity.•Glyphosate and AMPA affect neuronal development related gene transcriptions.•Glyphosate and AMPA affect gene expression profiling of cell death pathways.

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关键词

Glyphosate,Neurotoxicity,SH-SY5Y cells,Oxidative stress,Cell death pathways,Risk factors

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