Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins.
EUROPEAN JOURNAL OF IMMUNOLOGY(2020)
摘要
We have analyzed T cell receptor repertoires in a unique set of thymus samples from a pair of monozygotic twins. While genetics affect the V(D)J rearrangement and generation of junctional sequences, the thymic selections seem largely stochastic and import no detectable inheritable effect at clonal level.
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关键词
CDR3,genetics,TCR repertoire,thymic selection,twins
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