The Association Of Serum Vitamin D Level With The Severity Of Dry Eye Parameters In Primary Sjogren Syndrome

Purpose: To analyze the relationship between serum 25(OH)D(3)level and dry eye parameters in primary Sjogren syndrome (SS). Methods: This study included 74 eyes of 74 patients diagnosed with primary SS. Dry eye parameters included tear breakup time, Schirmer I value, corneal staining score, conjunctival staining score, and Ocular Surface Disease Index. The serum concentration of 25(OH)D(3)was evaluated. Results: The mean serum 25(OH)D(3)level was 20.4 +/- 8.0 ng/mL. There were strong negative correlations between serum 25(OH)D(3)level and corneal staining score (P< 0.001, r = -0.446) and conjunctival staining score (P< 0.001, r = -0.455). The Schirmer I value and tear breakup time showed significant positive correlations with serum 25(OH)D(3)level (P= 0.038, r = 0.261 andP= 0.003, r = 0.352, respectively). The Ocular Surface Disease Index did not show any significant correlation with serum 25(OH)D(3)level. Conclusions: This study demonstrates that serum 25(OH)D(3)level might be associated with dry eye severity in primary SS.