Role of cholesterol-mediated effects in GPCR heterodimers

Xavier Prasanna,Madhura Mohole,Amitabha Chattopadhyay,Durba Sengupta

Chemistry and Physics of Lipids（2020）

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摘要

•Cholesterol-dependent hetero-dimerization of adenosine2A and dopamine D3 receptors.•Novel cholesterol interaction sites on the dopamine D3 receptor monomer observed.•Cholesterol tunes relative populations of co-existing heterodimer conformations.•One of the first examples of GPCR heteromerization modulated by cholesterol.•Such lipid-dependent crosstalk between GPCRs could be therapeutically relevant.

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关键词

A2A receptor,D3 receptor,GPCR,POPC

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