Comparison of the gamma-Pareto convolution with conventional methods of characterising metformin pharmacokinetics in dogs

model was developed for long term metformin tissue retention based upon temporally inclusive models of serum/plasma concentration ( C ) having power function tails called the gamma-Pareto type I convolution (GPC) model and was contrasted with biexponential (E2) and noncompartmental (NC) metformin models. GPC models of C have a peripheral venous first arrival of drug-times parameter, early C peaks and very slow washouts of C . The GPC, E2 and NC models were applied to a total of 148 serum samples drawn from 20 min to 72 h following bolus intravenous metformin in seven healthy mongrel dogs. The GPC model was used to calculate area under the curve ( AUC ), clearance ( CL ), and functions of time, f ( t ), for drug mass remaining ( M ), apparent volume of distribution ( V_d ), as well as t_1/2 f(t) for C , M and V_d . The GPC models of C yielded metformin CL -values that were 84.8