Development and validation of an LC-MS/MS method for the quantification of goserelin in a Pheroid® formulation, in simulated intestinal fluid.

John Takyi-Williams,Linnè Erasmus,Rose Hayeshi,Anne Grobler

Journal of Pharmaceutical and Biomedical Analysis（2020）

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摘要

•The mixture of simulated intestinal fluid and Pheroid® formulation produced a complex matrix.•Simultaneous double extraction procedure enabled efficient peptide recovery.•The method was rapid with acceptable specificity, linearity, accuracy, and precision.•The Pheroid® formulation could not improve goserelin stability in simulated intestinal fluid.

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关键词

Pheroid® formulation,Goserelin,LC-MS/MS,Peptide,Simulated intestinal fluid,Method validation

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