Complement Receptor 1 (CR1/CD35)-expressing retinal pigment epithelial cells as a potential therapy for age-related macular degeneration.

Ken T Simmons, John L Mazzilli,Stacey L Mueller-Ortiz, Aleksey Y Domozhirov,Charles A Garcia,Eva M Zsigmond,Rick A Wetsel

Molecular Immunology（2020）

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摘要

•CR1, a membrane-bound complement inhibitor, shows little to no expression on RPE.•Stable transfection produced a CR1-expressing ARPE19 line.•CR1-expressing ARPE19 were significantly protected from complement deposition.

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关键词

AMD,CHO,CR1,FH-Dpl,hESC,hESC-RPE,HI-FBS,MAC,QPCR,RPE

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